Mental health, Reproductive health and contraception: pharmacological interaction, current evidence and challenges

Introduction Mental pathology is relatively prevalent in the women, and there often a need for treatment with psychotropic drugs, an impact on women’s reproductive health. The use of contraception widely spread among this population choice between these methods must be considered carefully. Objectives This review aims to present main interactions contraceptive therapy its psychiatric disorders, addition precautions taken their choice. Methods Literature relevant articles Pubmed. Query: Contraceptive+(psychiatric disorder, depression, anxiety, schizophrenia, bipolar drugs). Results Based current evidence, no statistically significant differences regarding unplanned pregnancy rates or outcomes were found when using combined oral contraceptives antidepressants, benzodiazepines atypical antipsychotics (being clozapine exception). mood was unclear, as some showed association higher risk beginning antidepressants others showing even protective factor. Although aforementioned drugs are infrequent, cases where important occur, such clozapine, valproic acid, lamotrigine carbamazepine, herbal products St.John’s wort. With increased serum concentrations, while opposite occurs case valproate decrease 32.6% 23.4%, respectively. Treatment acid women childbearing age has been discouraged because polycystic ovary syndrome, elevated testosterone concentrations menstrual irregularities, fetal malformations. In drug prescribed, it recommended highly effective subcutaneous implants intrauterine devices. Lamotrigine carbamazepine reduce effectiveness methods, contraceptives, transdermal patch vaginal ring, which placement implant device indicated. Conclusions magnitude depressive unclear. evidence shows that report appearance recrudescence symptoms, evidencing further studies identify factors cases. importance clear simple information shared decision choose crucial, clarification about treatment. clinician also aware implications health, order risks side effects associated drugs. Disclosure Interest None Declared